Zusammenfassung wissenschaftliche Originalpublikation

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Zusammenfassung einer wissenschaftlichen Originalpublikation: Harald zur Hausen et al., Deutsches Krebsforschungszentrum Heidelberg, 1983

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions

(...) Human genital cancer reveals epidemiological characteristics of infectious events. Two virus groups have been found to play a role: herpes simplex viruses and human papillomaviruses (HPVs). (...), we focused our interest on thepersistence of papillomavirus DNA within genital tumors.

Two types of genital papillomavirus infections have been regularly demonstrated in genital papillomas (...): HPV 6 and HPV 11. There may exist additional types within benign genital tumors.

(...) The presence of HPV 16 DNA in more than 60% of cervical cancer biopsy specimens from German patients and its absence from most benign papillomas from the same region is a startling observation. It reveals a remarkable specificity of HPV 16 infections for malignant tissue. This renders an accidental contamination from adjacent papilloma tissue rather unlikely.

(...) There seems to exist some geographic difference in the incidence of HPV 16 infections in human genital cancer. Only 34.8% of cervical cancer biopsy specimens obtained from Kenya and Brazil contained cross-hybridizing sequences. This may reflect the prevalence of other papillomavirus types in these regions. (...) It is thus apparent that different types of papillomaviruses can be found in genital squamous cell carcinomas. (...) At present, the total percentage of positive cervical cancer biopsy samples (German cases) amounts to 72%. We do expect that characterization of further types of HPV will increase the percentage of positive tumors. The regulär presence of HPV DNA in genital cancer biopsy samples does not per se prove an etiological involvement of these virus infections, although the apparent cancer specificity of HPV 16 is suggestive of such a role. Their biological significance äs well äs the proposed interaction with initiating events certainly requires further investigation.

Glossar:

papillomavirus : Papillom- oder Warzenviren cervical

carcinoma : Zervixkarzinom, Gebärmutterhalskrebs

prevalence : Prävalenz (= Häufigkeit einer Erkrankung / eines Merkmals zu einem bestimmten Zeitpunkt)

biopsy : Gewebeprobe

persistence : hier: Vorkommen; sonst: Ausdauer

papilloma : Warze

benign : gutartig

specimen : Probe

startling : überraschend

malignant : bösartig

accidental : zufällig, unbeabsichtigt contamination: Verunreinigung

adjacent : benachbart

tissue : Gewebe

squamous cell : Plattenepithelzelle (= plattenartig geformte Zellen oberflächlicher Abschlussgewebe)

etiological : ursächlich involvement Beteiligung

apparent : offensichtlich

to be suggestive of sth .: auf etw. hindeuten

Quelle:

Journal "Proceedings of the National Academy of Sciences", USA, Vol. 80, pp. 3812-3815, Juni 1983