Zu­sam­men­fas­sung wis­sen­schaft­li­che Ori­gi­nal­pu­bli­ka­ti­on

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Zu­sam­men­fas­sung einer wis­sen­schaft­li­chen Ori­gi­nal­pu­bli­ka­ti­on: Ha­rald zur Hau­sen et al., Deut­sches Krebs­for­schungs­zen­trum Hei­del­berg, 1983

A pa­pil­lo­ma­vi­rus DNA from a cer­vical car­ci­no­ma and its pre­va­lence in can­cer bi­o­psy sam­ples from dif­fe­rent geo­gra­phic re­gi­ons

(...) Human ge­ni­tal can­cer re­veals epi­de­mio­lo­gi­cal cha­rac­te­ris­tics of in­fec­tious events. Two virus groups have been found to play a role: her­pes sim­plex vi­ru­s­es and human pa­pil­lo­ma­vi­ru­s­es (HPVs). (...), we fo­cu­sed our in­te­rest on the­per­sis­tence of pa­pil­lo­ma­vi­rus DNA wi­t­hin ge­ni­tal tu­mors.

Two types of ge­ni­tal pa­pil­lo­ma­vi­rus in­fec­tions have been re­gu­lar­ly de­mons­tra­ted in ge­ni­tal pa­pil­lo­mas (...): HPV 6 and HPV 11. There may exist ad­di­tio­nal types wi­t­hin be­nign ge­ni­tal tu­mors.

(...) The pre­sence of HPV 16 DNA in more than 60% of cer­vical can­cer bi­o­psy spe­ci­mens from Ger­man pa­ti­ents and its ab­sence from most be­nign pa­pil­lo­mas from the same re­gi­on is a start­ling ob­ser­va­ti­on. It re­veals a re­mar­ka­ble spe­ci­fi­ci­ty of HPV 16 in­fec­tions for ma­li­gnant tis­sue. This ren­ders an ac­ci­den­tal con­ta­mi­na­ti­on from ad­ja­cent pa­pil­lo­ma tis­sue ra­ther un­li­kely.

(...) There seems to exist some geo­gra­phic dif­fe­rence in the in­ci­dence of HPV 16 in­fec­tions in human ge­ni­tal can­cer. Only 34.8% of cer­vical can­cer bi­o­psy spe­ci­mens ob­tai­ned from Kenya and Bra­zil con­tai­ned cross-hy­bri­di­zing se­quen­ces. This may re­flect the pre­va­lence of other pa­pil­lo­ma­vi­rus types in these re­gi­ons. (...) It is thus ap­pa­rent that dif­fe­rent types of pa­pil­lo­ma­vi­ru­s­es can be found in ge­ni­tal squa­mous cell car­ci­no­mas. (...) At pre­sent, the total per­cen­ta­ge of po­si­ti­ve cer­vical can­cer bi­o­psy sam­ples (Ger­man cases) amounts to 72%. We do ex­pect that cha­rac­te­riza­t­i­on of fur­ther types of HPV will in­crea­se the per­cen­ta­ge of po­si­ti­ve tu­mors. The re­gu­lär pre­sence of HPV DNA in ge­ni­tal can­cer bi­o­psy sam­ples does not per se prove an etio­lo­gi­cal in­vol­ve­ment of these virus in­fec­tions, alt­hough the ap­pa­rent can­cer spe­ci­fi­ci­ty of HPV 16 is sug­ges­ti­ve of such a role. Their bio­lo­gi­cal si­gni­fi­can­ce äs well äs the pro­po­sed in­ter­ac­tion with in­itia­ting events cer­tain­ly re­qui­res fur­ther in­ves­ti­ga­ti­on.

Glos­sar:

pa­pil­lo­ma­vi­rus : Pa­pil­lom- oder War­zen­vi­ren cer­vical

car­ci­no­ma : Zer­vix­kar­zi­nom, Ge­bär­mut­ter­hals­krebs

pre­va­lence : Prä­va­lenz (= Häu­fig­keit einer Er­kran­kung / eines Merk­mals zu einem be­stimm­ten Zeit­punkt)

bi­o­psy : Ge­we­be­pro­be

per­sis­tence : hier: Vor­kom­men; sonst: Aus­dau­er

pa­pil­lo­ma : Warze

be­nign : gut­ar­tig

spe­ci­men : Probe

start­ling : über­ra­schend

ma­li­gnant : bös­ar­tig

ac­ci­den­tal : zu­fäl­lig, un­be­ab­sich­tigt con­ta­mi­na­ti­on: Ver­un­rei­ni­gung

ad­ja­cent : be­nach­bart

tis­sue : Ge­we­be

squa­mous cell : Plat­te­ne­pi­t­hel­zel­le (= plat­ten­ar­tig ge­form­te Zel­len ober­fläch­li­cher Ab­schluss­ge­we­be)

etio­lo­gi­cal : ur­säch­lich in­vol­ve­ment Be­tei­li­gung

ap­pa­rent : of­fen­sicht­lich

to be sug­ges­ti­ve of sth .: auf etw. hin­deu­ten

Quel­le:

Jour­nal "Pro­cee­dings of the Na­tio­nal Aca­de­my of Sci­en­ces", USA, Vol. 80, pp. 3812-3815, Juni 1983